Effect of Coenzyme Q₁₀ on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ₁₀ Biomarker Trial.

ABSTRACT:

Background

Oxidative stress is highly prevalent in patients with end-stage renal disease and is linked to excess cardiovascular risk. Identifying therapies that reduce oxidative stress has the potential to improve cardiovascular outcomes in patients undergoing maintenance dialysis.

Study design

Placebo-controlled, 3-arm, double-blind, randomized, clinical trial.

Setting & participants

65 patients undergoing thrice-weekly maintenance hemodialysis.

Intervention

Patients were randomly assigned in a 1:1:1 ratio to receive once-daily coenzyme Q₁₀ (CoQ₁₀; 600 or 1,200mg) or matching placebo for 4 months.

Outcomes

The primary outcome was plasma oxidative stress, defined as plasma concentration of F₂-isoprotanes. Secondary outcom

SUBMITTER: Rivara MB 

PROVIDER: S-EPMC5616172 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature