A20 Restrains Thymic Regulatory T Cell Development.

ABSTRACT: Maintaining immune tolerance requires the production of Foxp3-expressing regulatory T (T_reg) cells in the thymus. Activation of NF-κB transcription factors is critically required for T_reg cell development, partly via initiating Foxp3 expression. NF-κB activation is controlled by a negative feedback regulation through the ubiquitin editing enzyme A20, which reduces proinflammatory signaling in myeloid cells and B cells. In naive CD4⁺ T cells, A20 prevents kinase RIPK3-dependent necroptosis. Using mice deficient for A20 in T lineage cells, we show that thymic and peripheral T_reg cell compartments are quantitatively enlarged because of a cell-intrinsic developmental advantage of A20-deficient thymic T_reg differentiation. A20-deficient thy

SUBMITTER: Fischer JC 

PROVIDER: S-EPMC5617121 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature