Aging and death-associated changes in serum albumin variability over the course of chronic hemodialysis treatment.

ABSTRACT:

Background

Several epidemiological studies have demonstrated associations between variability in a number of biological parameters and adverse outcomes. As the variability may reflect impaired homeostatic regulation, we assessed albumin variability over time in chronic hemodialysis (HD) patients.

Methods

Data from 1346 subjects who received chronic HD treatment from May 2001 to February 2015 were analyzed according to three phases of HD treatment: post-HD initiation, during maintenance HD treatment, and before death. The serum albumin values were grouped according to the time interval from HD initiation or death, and the yearly trends for both the albumin levels and the intra-individual albumin variability (quantified by the residual coefficient of variation: Alb-rCV) were e

SUBMITTER: Nakazato Y 

PROVIDER: S-EPMC5617180 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature