Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

ABSTRACT: G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT₁), its associated G protein, and β-arrestins are on and within neuronal mitochondria. We discovered that the ligand melatonin is exclusively synthesized in the mitochondrial matrix and released by the organelle activating the mitochondrial MT₁ signal-transduction pathway inhibiting stress-mediated cytochrome c release and caspase activation. These findings coupled with our observation that mitochondrial MT₁ overexpression reduces ischemic brain injury in mice delineate a mitochondrial GPCR mechanism contr

SUBMITTER: Suofu Y 

PROVIDER: S-EPMC5617277 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature