Janus Nanoparticles for T Cell Activation: Clustering Ligands to Enhance Stimulation.

ABSTRACT: The in vitro activation of T cells by synthetic particles is a promising technique for adoptive cancer immunotherapy. While it is known that cell-surface receptors form clusters during T cell activation, the use of clustered ligands on synthetic particles to modulate T cell response is a largely unexplored concept. Building upon our previous finding that T cells respond differently to various micro-sized patterns of ligands, we here investigate the effect of nano-sized ligand clusters on T cell activation. Two-faced Janus nanoparticles were fabricated to display ligands of different functions in spatially segregated clusters on single nanoparticles. Going beyond our earlier qualitative study, here we precisely quantified and controlled the surface density and the total amount of lig

SUBMITTER: Lee K 

PROVIDER: S-EPMC5617359 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature