Analysis of region specific gene expression patterns in the heart and systemic responses after experimental myocardial ischemia.

ABSTRACT:

Aims

Ischemic myocardial injury leads to the activation of inflammatory mechanisms and results in ventricular remodeling. Although great efforts have been made to unravel the molecular and cellular processes taking place in the ischemic myocardium, little is known about the effects on the surrounding tissue and other organs. The aim of this study was to determine region specific differences in the myocardium and in distant organs after experimental myocardial infarction by using a bioinformatics approach.

Methods and results

A porcine closed chest reperfused acute myocardial infarction model and mRNA microarrays have been used to evaluate gene expression changes. Myocardial infarction changed the expression of 8903 genes in myocardial-, 856 in hepatic- and 338 in splenic tis

SUBMITTER: Zimmermann M 

PROVIDER: S-EPMC5617387 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature