Epigenetic hypomethylation and upregulation of matrix metalloproteinase 9 in Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease (KD) is a type of febrile coronary vasculitis occurring in children. Some researchers have suggested that changes in genetic signatures, such as matrix metalloproteinases (MMPs), are critical markers for cardiovascular diseases. This study aims to provide a comprehensive survey of global DNA methylation levels and MMP transcripts of KD patients compared to control subjects.

Materials and methods

For chips studies, we recruited a total of 18 KD patients, prior to receiving intravenous immunoglobulin (IVIG) and at least 3 weeks after IVIG treatment, as well as 18 healthy and 18 febrile control subjects. We applied Illumina HumanMethylation450 BeadChip and Affymetrix GeneChip® Human Transcriptome Array 2.0 to evaluate their CpG markers and expression

SUBMITTER: Kuo HC 

PROVIDER: S-EPMC5617391 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature