Integrated transcriptomic analysis of distance-related field cancerization in rectal cancer patients.

ABSTRACT: Field cancerization (FC) occurs in various epithelial carcinomas, including colorectal cancer, which indicates that the molecular events in carcinogenesis might occur in normal tissues extending from tumors. However, the transcriptomic characteristics of FC in colorectal cancer (CRC) remain largely unexplored. To investigate the changes in gene expression associated with proximity to the tumor, we analyzed the global gene expression profiles of cancer tissues and histologically normal tissues taken at various distances from the tumor (1 cm, 5 cm and the proximal end of the resected sample) from 32 rectal cancer patients. Significantly differentially expressed genes related to the distance from the tumor were screened by linear mixed effects analysis using the lme4 package in R. The distanc

SUBMITTER: Guo H 

PROVIDER: S-EPMC5617410 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature