Characteristics of ovarian cancer detection by a near-infrared fluorescent probe activated by human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1).

ABSTRACT: Near-infrared (NIR) fluorescent probes are ideal for in vivo imaging, because they offer deeper tissue penetration by the light and lower background autofluorescence than fluorophores that emit in the visible range. Q₃STCy is a newly synthesized, NIR light-emitting probe that is activated by an enzyme commonly overexpressed in tumor cells, human nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase isozyme 1, known as hNQO1 or DT-diaphorase. The purpose of this study is to compare the sensitivity of detecting peritoneal ovarian cancer metastasis (POCM) with Q₃STCy and gGlu-HMRG, a green fluorescent probe, upon their surface application. In vitro uptake of Q₃STCy was significantly higher than that of gGlu-HMRG. Using a red fluor

SUBMITTER: Nakamura Y 

PROVIDER: S-EPMC5617415 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature