Overexpression of stathmin plays a pivotal role in the metastasis of esophageal squamous cell carcinoma.

ABSTRACT:

Purpose

Esophageal squamous cell carcinoma (ESCC) is a serious malignant tumor that affects human health. We analyzed the correlation between serum stathmin level and ESCC and elucidated the molecular mechanisms of stathmin's promotion of ESCC cell invasion and metastasis.

Methods

Stathmin level in ESCC and healthy control serum were detected by enzyme-linked immunosorbent assay (ELISA), and the clinical parameters were analyzed. We established ESCC cells with stathmin overexpression or knockdown and then evaluated the effects of stathmin on invasion and metastasis in ESCC. Differentially expressed genes were analyzed by Human Transcriptome Array and confirmed by RT-PCR. The expression levels of the integrin family, focal adhesion kinase (FAK) and extracellular signal-regula

SUBMITTER: Han G 

PROVIDER: S-EPMC5617461 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature