Gene expression profiling to predict recurrence of advanced squamous cell carcinoma of the tongue: discovery and external validation.

ABSTRACT:

Objectives

To establish a prognostic signature for locally advanced tongue squamous cell carcinoma (TSCC) patients treated with surgery.

Results

In the discovery study, unsupervised hierarchical clustering analysis identified two clusters which differentiated the Kaplan-Meier curves of RFS [median RFS, 111 days vs. not reached; log-rank test, P = 0.023]. The 30 genes identified were combined into a dichotomous PI. In the validation cohort, classification according to the PI was associated with RFS [median RFS, 754 days vs. not reached; log-rank test, P = 0.026 in GSE31056] and DSS [median DSS, 540 days vs. not reached; log-rank test, P = 0.046 in GSE42743 and 443 days vs. not reached; P < 0.001 in GSE41613]. Among genes, positive immunohistochemic

SUBMITTER: Enokida T 

PROVIDER: S-EPMC5617464 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature