Association between TGFB1 genetic polymorphisms and chronic allograft dysfunction: a systematic review and meta-analysis.

ABSTRACT:

Background

Epidemiological studies have investigated the role of transforming growth factor-β1 (TGF-β1) in chronic allograft dysfunction (CAD) following kidney transplantation. TGFB1 gene polymorphisms (SNP rs1800470 and rs1800471) may be associated with the risk of CAD. In this meta-analysis, the relationship between these two variations and the risk of CAD was explored.

Materials and methods

MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Embase, the Chinese CNKI and WANFANG databases were searched. Data were extracted and pooled results were estimated from odds ratios (ORs) with 95% confidential intervals (95% CIs). Quality assessments were performed, and publication bias of all eligible studies examined.

Results

Eight studies

SUBMITTER: Liu K 

PROVIDER: S-EPMC5617520 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature