Increased mortality for colorectal cancer patients with preexisting diabetes mellitus: an updated meta-analysis.

ABSTRACT:

Background

Although the preexisting diabetes mellitus (DM) is known to have a high risk for death in many cancers, its impact on the mortality for the colorectal cancer (CRC) patients is still uncertain. In this study, we conducted a meta-analysis to explore an association of DM with the survival for the CRC patients.

Materials and methods

We made a relative data search from the public available databases including Medline and Embase with a cutoff date to Jan 31, 2017. Pooled hazard ratios (HRs) were calculated using either a fixed or random effect model. Trim and fill analysis was conducted to test and adjust for publication bias. Subgroup analyses were also performed for overall survival and all-cause mortality when stratified by tumor stage, geographical region, duration

SUBMITTER: Li J 

PROVIDER: S-EPMC5617522 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature