Meta-analysis of associations between telomere length and colorectal cancer survival from observational studies.

ABSTRACT:

Background

Telomere length (TL) has been reported to be associated with the risk and survival of several cancers. But it is unclear for the prognostic role of TL in colorectal cancer (CRC).

Materials and methods

Relevant citations were searched and identified using several major online databases through April 2017 which investigated associations between TL and CRC prognosis. We combined summary estimates using hazard ratios (HRs) with 95% confidence interval (CI), which were pooled using a random-effects model. Overall survival (OS) was set as the primary outcome of interest.

Results

There are 8 cohort studies encompassing 1622 patients included in the meta-analysis. Pooled estimate indicated that long TL was not significantly associated with patient OS (HR 1.26, 95%

SUBMITTER: Wang W 

PROVIDER: S-EPMC5617524 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature