Multiparametric imaging using ¹⁸F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy.

ABSTRACT:

Background

In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC).

Methods

A total of 124 patients with primary advanced OHSCC who underwent pretreatment ¹⁸F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from ¹⁸F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS).

Results

Multivariate analysis identified hypopharyngeal tumors (P = 0.038), alcohol drinking

SUBMITTER: Chan SC 

PROVIDER: S-EPMC5617533 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature