Cancer risk in first- and second-degree relatives of men with poor semen quality.

ABSTRACT:

Objective

To further characterize the association of male infertility with health risks by evaluating semen quality and cancer risk in family members.

Design

Retrospective, cohort study.

Setting

Not applicable.

Patient(s)

A total of 12,889 men undergoing SA and 12,889 fertile control subjects that had first-degree relative (FDR) data (n = 130,689) and 8,032 men with SA and 8,032 fertile control subjects with complete second-degree relative (SDR) data (n = 247,204) were identified through the UPDB. An equal number of fertile population control subjects were matched.

Interventions

None.

Main outcome measure(s)

Adult all-site, testicular, thyroid, breast, prostate, melanoma, bladder, ovarian, and kidney cancer diagnoses in FDRs and SDRs.

Result(s)

SUBMITTER: Anderson RE 

PROVIDER: S-EPMC5617641 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature