Cytotoxicity, hemolysis and in vivo acute toxicity of 2-hydroxy-3-anilino-1,4-naphthoquinone derivatives.

ABSTRACT: The 1,4-naphthoquinones, important members of the family of quinones are used as both crude extracts and as compound manipulated by the pharmaceutical industry. They have gained great emphasis by presenting different pharmacological properties as antibacterial, antiviral, antiprotozoal and anthelmintic, and has antitumor activity. Our aim was to evaluate the cytotoxicity, hemolytic activity and in vivo acute toxicity of three derivatives of 2-hydroxy-1,4-naphthoquinones. The cell viability in vitro against RAW Cell Line displayed IC₅₀ ranging of 483.5-2044.8 μM, whereas in primary culture tests using murine macrophages, IC₅₀ were 315.8-1408.0 μM for naphthoquinones derivatives 4a and 4c respectively, besides no hemolysis was observed at the

SUBMITTER: de Sena Pereira VS 

PROVIDER: S-EPMC5617738 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature