Thresholds for PSA doubling time in men with non-metastatic castration-resistant prostate cancer.

ABSTRACT:

Objectives

To examine whether prostate-specific antigen doubling time (PSADT) correlates with metastases, all-cause mortality (ACM), and prostate cancer-specific mortality (PCSM) and to identify PSADT thresholds that can be used clinically for risk stratification in men with M0 castration-resistant prostate cancer (CRPC).

Materials and methods

We collected data on 441 men with M0 CRPC in 2000-2015 at five Veterans Affairs hospitals. Cox models were used to test the association between log-transformed PSADT and the development of metastasis, ACM and PCSM. To identify thresholds, we categorized PSADT into 3-month groups and then combined groups with similar hazard ratios (HRs).

Results

The median (interquartile range) follow-up was 28.3 (14.7-49.1) months. As a continuo

SUBMITTER: Howard LE 

PROVIDER: S-EPMC5617753 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature