Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free ⁶⁴Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer.

ABSTRACT: Developing tumor-homing nanoparticles with integrated diagnostic and therapeutic functions, and meanwhile could be rapidly excreted from the body, would be of great interest to realize imaging-guided precision treatment of cancer. In this study, an ultrasmall coordination polymer nanodot (CPN) based on the coordination between tungsten ions (W^VI) and gallic acid (W-GA) was developed via a simple method. After polyethylene glycol (PEG) modification, PEGylated W-GA (W-GA-PEG) CPNs with an ultrasmall hydrodynamic diameter of 5 nm were rather stable in various physiological solutions. Without the need of chelator molecules, W-GA-PEG CPNs could be efficiently labeled with radioisotope ⁶⁴Cu²⁺, enabling positron emission tomography (PET) imaging, which reveals eff

SUBMITTER: Shen S 

PROVIDER: S-EPMC5617799 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature