Mn2+-ZnSe/ZnS@SiO₂ Nanoparticles for Turn-on Luminescence Thiol Detection.

ABSTRACT: Biological thiols are antioxidants essential for the prevention of disease. For example, low levels of the tripeptide glutathione are associated with heart disease, cancer, and dementia. Mn2+-doped wide bandgap semiconductor nanocrystals exhibit luminescence and magnetic properties that make them attractive for bimodal imaging. We found that these nanocrystals and silica-encapsulated nanoparticle derivatives exhibit enhanced luminescence in the presence of thiols in both organic solvent and aqueous solution. The key to using these nanocrystals as sensors is control over their surfaces. The addition of a ZnS barrier layer or shell produces more stable nanocrystals that are isolated from their surroundings, and luminescence enhancement is only observed with thinner, intermediate shells. Tuna

SUBMITTER: Yazdanparast MS 

PROVIDER: S-EPMC5618287 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature