A pH responsive complexation-based drug delivery system for oxaliplatin.

ABSTRACT: A responsive drug delivery system (DDS) for oxaliplatin (OX) has been designed with a view to overcoming several drawbacks associated with this anticancer agent, including fast degradation/deactivation in the blood stream, lack of tumor selectivity, and low bioavailability. The present approach is based on the direct host-guest encapsulation of OX by a pH-responsive receptor, carboxylatopillar[6]arene (CP6A). The binding affinities of CP6A for OX were found to be pH-sensitive at biologically relevant pH. For example, the association constant (K_a) at pH 7.4 [K_a = (1.02 ± 0.05) × 10⁴ M^-1] is 24 times larger than that at pH 5.4 [K_a = (4.21 ± 0.06) × 10² M^-1]. En

SUBMITTER: Li B 

PROVIDER: S-EPMC5618340 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature