Histologic Normalization Occurs in Ulcerative Colitis and Is Associated With Improved Clinical Outcomes.

ABSTRACT:

Background & aims

Mucosal healing, determined by histologic analysis, is a potential therapeutic target for patients with ulcerative colitis (UC). However, the histologic features of tissue normalization, as an outcome of treatment, have not been well described. We examined the prevalence and predictive values of normalization of the colonic mucosa, based on histologic analysis (histologic normalization) in patients with UC, and determined its association with risk of clinical relapse, compared with histologic disease quiescence and endoscopic mucosal healing.

Methods

We performed a retrospective study of 646 patients with confirmed UC who underwent colonoscopy at a tertiary medical center from August 2005 through October 2013. We reviewed reports from pathology analyses of

SUBMITTER: Christensen B 

PROVIDER: S-EPMC5618439 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature