3D Printed, Microgroove Pattern-Driven Generation of Oriented Ligamentous Architectures.

ABSTRACT: Specific orientations of regenerated ligaments are crucially required for mechanoresponsive properties and various biomechanical adaptations, which are the key interplay to support mineralized tissues. Although various 2D platforms or 3D printing systems can guide cellular activities or aligned organizations, it remains a challenge to develop ligament-guided, 3D architectures with the angular controllability for parallel, oblique or perpendicular orientations of cells required for biomechanical support of organs. Here, we show the use of scaffold design by additive manufacturing for specific topographies or angulated microgroove patterns to control cell orientations such as parallel (0°), oblique (45°) and perpendicular (90°) angulations. These results demonstrate that ligament cells displ

SUBMITTER: Park CH 

PROVIDER: S-EPMC5618576 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature