Novel Insights into the Adipokinome of Obese and Obese/Diabetic Mouse Models.

ABSTRACT: The group of adipokines comprises hundreds of biological active proteins and peptides released from adipose tissue. Alterations of those complex protein signatures are suggested to play a crucial role in the pathophysiology of multifactorial, metabolic diseases. We hypothesized that also the pathophysiology of type-2-diabetes is linked to the dysregulation of the adipocyte secretome. To test this, we investigated mouse models with monogenic defects in leptin signaling which are susceptible to adipositas (C57BL/6 Cg-Lep^ob (obob)) or adipositas with diabetes (C57BL/KS Cg-Lepr^db (dbdb)) according to their genetic background. At the age of 17 weeks, visceral fat was obtained and primary murine adipocytes were isolated to harvest secretomes. Quantitative proteome analyses

SUBMITTER: Knebel B 

PROVIDER: S-EPMC5618577 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature