Dual inhibition of BDNF/TrkB and autophagy: a promising therapeutic approach for colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) is the most common digestive cancer in the Western world. Despite effective therapies, resistance and/or recurrence frequently occur. The present study investigated the impact of two survival pathways-neurotrophic factors (TrkB/BDNF) and autophagy-on cell fate and tumour evolution. In vitro studies were performed on two CRC cell lines, SW480 (primary tumour) and SW620 (lymph node invasion), which were also used for subcutaneous xenografts on a nude mouse model. In addition, the presence of neurotrophic factors (NTs) and autophagy markers were assessed in tissue samples representative of different stages. On the basis of our previous study (which demonstrated that TrkB overexpression is associated with prosurvival signaling in CRC cells), we pharmacologically inhibit

SUBMITTER: Mazouffre C 

PROVIDER: S-EPMC5618676 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature