Clusterin modulates transdifferentiation of non-small-cell lung cancer.

ABSTRACT:

Background

Secreted clusterin (sCLU), a 75-80 kDa disulfide-linked heterodimeric protein, plays crucial roles in various pathophysiological processes, including lipid transport, tissue remodeling, cell apoptosis and reproduction. Our previous studies demonstrated that sCLU could influence cell apoptosis, proliferation, and invasion of non-small cell lung cancer (NSCLC) cells.

Methods

In this study, clusterin's function in regulating transdifferentiation of NSCLC cells was investigated. In addition, we examined the correlation between clusterin and clinicopathological features of lung cancer.

Results

We found that clusterin was increased in lung adenocarcinoma tissues and decreased in lung squamous cell carcinoma tissues through immunohistochemical technique. In cultur

SUBMITTER: Jin R 

PROVIDER: S-EPMC5618728 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature