Ldt_Mav2, a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems.

ABSTRACT:

Aim

Mycobacterium avium infections, especially in immune-compromised individuals, present a significant challenge as therapeutic options are limited. In this study, we investigated if M. avium genome encodes nonclassical transpeptidases and if newer carbapenems are effective against this mycobacteria.

Materials & methods

Biochemical and microbiological approaches were used to identify and characterize a nonclassical transpeptidase, namely L,D-transpeptidase, in M. avium.

Results & conclusion

We describe the biochemical and physiological attributes of a L,D-transpeptidase in M. avium, Ldt_Mav2. Suggestive of a constitutive requirement, levels of Ldt_Mav2, a L,D-transpeptidase in M. avium, remain constant during exponential and stationary phases of g

SUBMITTER: Mattoo R 

PROVIDER: S-EPMC5619143 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature