Evaluating Utility Measurement from Recurrent Marker Processes in the Presence of Competing Terminal Events.

ABSTRACT: In follow-up studies, utility marker measurements are usually collected upon the occurrence of recurrent events until a terminal event such as death takes place. In this article, we define the recurrent marker process to characterize utility accumulation over time. For example, with medical cost and repeated hospitalizations being treated as marker and recurrent events respectively, the recurrent marker process is the trajectory of cumulative cost, which stops to increase after death. In many applications, competing risks arise as subjects are at risk of more than one mutually exclusive terminal event, such as death from different causes, and modeling the recurrent marker process for each failure type is often of interest. However, censoring creates challenges in the methodological develop

SUBMITTER: Sun Y 

PROVIDER: S-EPMC5619681 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature