A prospective, observational study of patients with uncommon distal symmetric painful small-fiber neuropathy.

ABSTRACT:

Objective

To investigate the clinical characteristics of patients with uncommon distal symmetric painful small-fiber neuropathy (DSPSFN).

Methods

From September 2012 to September 2014, participants between 18-70 years of age that had DSPSFN defined by clinical signs/symptoms and ID pain > 2 or DN4 > 4 on questionnaires for more than 1 month were included. Participants who had previous historical or laboratory evidence of common etiologies of DSPSFN were excluded. Enzyme activity and genetic studies for Fabry diseaseand familial amyloid polyneuropathy were performed after participants fulfilled the inclusion and exclusion criteria. The cryoglobulin test, autoantibodies studies and electrophysiological studies were performed in these participants.

Results

In total, 100

SUBMITTER: Hsu JL 

PROVIDER: S-EPMC5619719 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature