Evaluation of a new set of recombinant antigens for the serological diagnosis of human and canine visceral leishmaniasis.

ABSTRACT: Current strategies for the control of zoonotic visceral leishmaniasis (VL) rely on its efficient diagnosis in both human and canine hosts. The most promising and cost effective approach is based on serologic assays with recombinant proteins. However, no single antigen has been found so far which can be effectively used to detect the disease in both dogs and humans. In previous works, we identified Leishmania infantum antigens with potential for the serodiagnosis of VL. Here, we aimed to expand the panel of the available antigens for VL diagnosis through another screening of a genomic expression library. Seven different protein-coding gene fragments were identified, five of which encoding proteins which have not been previously studied in Leishmania and rich in repetitive motifs. Poly-histi

SUBMITTER: Magalhaes FB 

PROVIDER: S-EPMC5619722 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature