Medication adherence, medical record accuracy, and medication exposure in real-world patients using comprehensive medication monitoring.

ABSTRACT:

Background

Poor adherence to medication regimens and medical record inconsistencies result in incomplete knowledge of medication therapy in polypharmacy patients. By quantitatively identifying medications in the blood of patients and reconciling detected medications with the medical record, we have defined the severity of this knowledge gap and created a path toward optimizing medication therapy.

Methods and findings

We validated a liquid chromatography-tandem mass spectrometry assay to detect and/or quantify 38 medications across a broad range of chronic diseases to obtain a comprehensive survey of patient adherence, medical record accuracy, and exposure variability in two patient populations. In a retrospectively tested 821-patient cohort representing U.S. adults, we found

SUBMITTER: Ryan TP 

PROVIDER: S-EPMC5619774 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature