Association between matrix metalloproteinases polymorphisms and ovarian cancer risk: A meta-analysis and systematic review.

ABSTRACT:

Background

Published data on the relationship between matrix metalloproteinases (MMPs) polymorphisms and ovarian cancer risk have implicated inconclusive results. To evaluate the role of MMPs polymorphisms in ovarian cancer risk, a meta-analysis and systematic review were performed.

Methods

MMPs polymorphisms which could be quantitatively synthesized were involved in meta-analysis. Five comparison models (homozygote model, heterozygote model, dominant model, recessive model, additive model) were carried out, a subgroup analysis was performed to clarify heterogeneity source. The remaining polymorphisms which could not be quantitatively synthesized were involved in systematic review.

Results

10 articles with 20 studies were included in this paper. Among those studies, 8

SUBMITTER: Zhu XM 

PROVIDER: S-EPMC5619784 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature