Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis.

ABSTRACT: Monocytes are innate immune cells that play a pivotal role in antifungal immunity, but little is known regarding the cellular metabolic events that regulate their function during infection. Using complementary transcriptomic and immunological studies in human primary monocytes, we show that activation of monocytes by Candida albicans yeast and hyphae was accompanied by metabolic rewiring induced through C-type lectin-signaling pathways. We describe that the innate immune responses against Candida yeast are energy-demanding processes that lead to the mobilization of intracellular metabolite pools and require induction of glucose metabolism, oxidative phosphorylation and glutaminolysis, while responses to hyphae primarily rely on glycolysis. Experimental models of systemic candidiasis models

SUBMITTER: Dominguez-Andres J 

PROVIDER: S-EPMC5619837 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature