Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities.

ABSTRACT:

Objective

To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population.

Methods

Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922 Hispanics who underwent brain MRI as a cross-section of 2 community-based cohorts in the Northern Manhattan Study and the Washington Heights-Inwood Columbia Aging Project. Multiple linear modeling with PLINK was performed to examine the additive genetic effects on ln(WMHV) after controlling for age, sex, total intracranial volume, and principal components of ancestry. Gene-based tests of association were performed using VEGAS. Replication was performed in independent sampl

SUBMITTER: Beecham A 

PROVIDER: S-EPMC5619914 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature