Pregnancy-Induced Sensitization Promotes Sex Disparity in Living Donor Kidney Transplantation.

ABSTRACT: The presence of sex disparity in living donor kidney transplantation (LDKT) remains controversial. To determine if women fall behind men in LDKT evaluation, we performed an intention to treat study of 2587 candidates listed for kidney transplant at a single transplant center over 7 years. We found that women and men kidney transplant candidates engaged an equivalent type and number of prospective living donors. However, sex-specific differences in sensitization history and histocompatibility reduced the rate of LDKT for women by 30%. Pregnancy-induced incompatibility with spouse donors was limiting given that spouses were among the individuals most likely to complete donation. Notably, participation in a kidney paired exchange program eliminated sex-based differences in LDKT. Collectively,

SUBMITTER: Bromberger B 

PROVIDER: S-EPMC5619956 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature