Association of Sex with Risk of Kidney Graft Failure Differs by Age.

ABSTRACT: Prior studies of sex differences in kidney graft survival showed conflicting results. We hypothesized that the association between recipient sex and kidney graft failure risk differs by recipient age and donor sex. We evaluated 159,417 patients recorded in the Scientific Registry of Transplant Recipients database who received a first deceased-donor kidney transplant (1995-2013). We used time-varying Cox models to estimate the association between recipient sex and death-censored graft failure. Models, stratified on donor sex and adjusted for potential confounders, included a recipient sex by current age interaction term. Among recipients of male donors, females of all ages had significantly higher graft failure risks than males (adjusted hazard ratios 0-14 years: 1.51 [95% confidence interv

SUBMITTER: Lepeytre F 

PROVIDER: S-EPMC5619967 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature