Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis.

ABSTRACT: Mediating the expansion of vascular beds in many physiological and pathological settings, angiogenesis requires dynamic changes in endothelial cell behavior. However, the molecular mechanisms governing endothelial cell activity during different phases of vascular growth, remodeling, maturation, and quiescence remain elusive. Here, we characterize dynamic gene expression changes during postnatal development and identify critical angiogenic factors in mouse retinal endothelial cells. Using actively translating transcriptome analysis and in silico computational analyses, we determine candidate regulators controlling endothelial cell behavior at different developmental stages. We further show that one of the identified candidates, the transcription factor MafB, controls endothelial sprouting i

SUBMITTER: Jeong HW 

PROVIDER: S-EPMC5620061 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature