Dissecting genetic architecture of startle response in Drosophila melanogaster using multi-omics information.

ABSTRACT: Startle behavior is important for survival, and abnormal startle responses are related to several neurological diseases. Drosophila melanogaster provides a powerful system to investigate the genetic underpinnings of variation in startle behavior. Since mechanically induced, startle responses and environmental conditions can be readily quantified and precisely controlled. The 156 wild-derived fully sequenced lines of the Drosophila Genetic Reference Panel (DGRP) were used to identify SNPs and transcripts associated with variation in startle behavior. The results validated highly significant effects of 33 quantitative trait SNPs (QTSs) and 81 quantitative trait transcripts (QTTs) directly associated with phenotypic variation of startle response. We also detected QTT variation controlled by 2

SUBMITTER: Xue A 

PROVIDER: S-EPMC5620086 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature