Immunotherapy of WAP-T_NP mice with early stage mammary gland tumors.

ABSTRACT: The SV40 transgenic BALB/c mouse based WAP-T/WAP-T_NP model for triple-negative breast cancer allows the analysis of parameters influencing immunotherapeutic approaches. Except for WAP-T_NP tumors expressing the immune-dominant LCMV NP-epitope within SV40 T-antigen (T-Ag_NP) which is not expressed by T-Ag of WAP-T tumors, the tumors are extremely similar. Comparative anti-PD1/PD-L1 immunotherapy of WAP-T and WAP-T_NP mice supported the hypothesis that the immunogenicity of tumor antigen T-cell epitopes strongly influences the success of immune checkpoint blockade therapy, with highly immunogenic T-cell epitopes favoring rapid CTL exhaustion. Here we analyzed the immune response in NP8 mice during early times of tumor development. LCMV infection of la

SUBMITTER: Bruns M 

PROVIDER: S-EPMC5620212 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature