A six-long non-coding RNAs signature as a potential prognostic marker for survival prediction of ER-positive breast cancer patients.

ABSTRACT: Dysregulated expression of lncRNAs has been observed in various human complex diseases (including cancers) by recent transcriptional profiling studies, highlighting potentials of lncRNAs as biomarkers for cancer diagnosis and prognosis. Despite some efforts have been made to search for novel lncRNA signature in breast cancer, the prognostic value of lncRNAs for ER-positive breast cancer patients still needs to be systematically investigated. In this study, we analyzed lncRNA expression profiles in a large of more than 600 breast cancer patients with ER-positive status from The Cancer Genome Atlas (TCGA) and identified six lncRNAs that are significantly associated with survival. Then a linear risk score model comprising six prognostic lncRNAs, termed six-lncRNA signature, was developed to i

SUBMITTER: Zhong L 

PROVIDER: S-EPMC5620219 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature