Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.

ABSTRACT: Pyruvate kinase M2 (PKM2) has been verified to correlate with the prognosis of many types of cancer. However, its role in the development and metastasis of tongue squamous cell carcinoma (TSCC) remains unclear. The immunohistochemistry (IHC) results confirmed that PKM2 is overexpressed in patients with TSCC. PKM2 up-regulation was related to lymph node metastasis and associated with reduced overall survival. According to the microarray analysis and Western blots, PKM2 expression was up-regulated in TSCC cells with enhanced metastatic potential. PKM2 knockdown inhibited cell migration and invasion, reduced SOD2 (manganese superoxide dismutase) activity and the intracellular H₂O₂ level, and inhibited tumour growth and lung metastasis in vivo. PKM2 overexpression

SUBMITTER: Wang W 

PROVIDER: S-EPMC5620253 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature