Ex vivo multiplex profiling of protein tyrosine kinase activities in early stages of human lung adenocarcinoma.

ABSTRACT: Despite constant improvement in existing therapeutic efforts, the overall survival rate of lung cancer patients remains low. Enzyme activities may identify new therapeutically targetable biomarkers and overcome the marked lack of correlation between cellular abundance of translated proteins and corresponding mRNA expression levels. We analysed tyrosine kinase activities to classify lung adenocarcinoma (LuAdCa) resection specimens based on their underlying changes in cellular processes and pathways that are agents of or result from malignant transformation. We characterised 71 same-patient pairs of early-stage LuAdCa and non-neoplastic LuAdCa resection specimen lysates in the presence or absence of a tyrosine kinase inhibitor. We performed ex vivo multiplex tyrosine phosphorylation a

SUBMITTER: Arni S 

PROVIDER: S-EPMC5620281 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature