Glioblastoma progression is assisted by induction of immunosuppressive function of pericytes through interaction with tumor cells.

ABSTRACT: The establishment of immune tolerance during Glioblastoma Multiforme (GBM) progression, is characterized by high levels expression of anti-inflammatory cytokines, which suppress the function of tumor assocciated myeloid cells, and the activation and expansion of tumor antigen specific T cells. However, the mechanisms underlying the failed anti-tumor immune response around the blood vessels during GBM, are poorly understood. The consequences of possible interactions between cancer cells and the perivascular compartment might affect the tumor growth. In this work we show for the first time that GBM cells induce immunomodulatory changes in pericytes in a cell interaction-dependent manner, acquiring an immunosuppresive function that possibly assists the evasion of the anti-tumor immune respons

SUBMITTER: Valdor R 

PROVIDER: S-EPMC5620282 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature