Concurrent somatic mutations in driver genes were significantly correlated with lymph node metastasis and pathological types in solid tumors.

ABSTRACT: To demonstrate the mutational profiles in solid tumors, we profiled 165 solid tumor samples, including 9 cancer types and 4 sample types, by using amplicon-based next-generation sequencing panel covering 48 highly mutated tumorigenesis-related genes that were deep sequenced at an average coverage of 2000×. Both tumor and sample types had significant effect on tumor genetic mutational profiles. Concurrent driver mutations were frequently detected in solid tumor, concentrating on both modes of action driver genes (activating or loss of function). Furthermore, in non-small cell lung cancer (NSCLC), concurrent driver mutations were also significantly correlated with the lymph node metastasis status and pathological types. Higher frequency of lymph node metastasis was observed in patients with

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC5620293 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature