Myoblast transplantation improves cardiac function after myocardial infarction through attenuating inflammatory responses.

ABSTRACT: Myocardial infarction (MI) is a highly prevalent cardiac emergency, which results in adverse cardiac remodeling and then exacerbates progressive heart failure. Inflammatory responses in cardiac tissue after MI is necessary for myocardium repair and wound healing. However, the excessive inflammation is also a key component of subsequent heart failure pathology. Myoblast transplantation after MI have been fulfilled attractive effects on cardiac repair, but the complications of transplantation and the underlying mechanisms have not been fully elucidated. Here, we found that human myoblast transplantation into minipig myocardium decreased the infiltration of inflammatory cells, the expression levels of many pro-inflammatory genes and the activation of inflammation-related signal pathways, whil

SUBMITTER: Wang B 

PROVIDER: S-EPMC5620296 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature