B7-H4 as an independent prognostic indicator of cancer patients: a meta-analysis.

ABSTRACT: The expression of B7-H4 was observed in a variety of tumors, however the prognostic value in cancer was still controversial. Therefore, we conducted this meta-analysis to explore the potential role of B7-H4 in cancer prognostic prediction. Twenty-seven studies including 3771 patients were brought into the analysis according to the inclusion and exclusion criteria. The pooled results demonstrated that elevated B7-H4 predicted a poor OS (HR = 1.93, 95% CI 1.71-2.18, P < 0.001) and DFS (HR = 1.84, 95% CI 1.46-2.33, P < 0.001). Subgroup analysis showed that races, tumor types, sample sources, analysis types, sources of HR and sample sizes exhibited non-significant distinctions with OS (P_S = 0.878, P_S = 0.143, P_S = 0.613, P_S = 0.639, P

SUBMITTER: Meng Z 

PROVIDER: S-EPMC5620299 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature