Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer.

ABSTRACT:

Background & aims

This study aims to analyze the feasibility and predictive value of thermal tomography (TT) for monitoring early treatment response in patients with locally advanced breast cancer (LABC) receiving neoadjuvant chemotherapy (NAC).

Methods

Patients with LABC who were due to receive six cycles of NAC were examined by TT prior to NAC, the second cycle of NAC, the fourth cycle of NAC and surgery. Changes in TT parameters and ultrasonography were correlated with pathologic response to NAC, and the predictive value was assessed.

Results

Forty-four patients were evaluable for response (25 pathologic responders and 19 nonresponders). As early as after the first cycle of NAC, changes in the TT parameters ΔTs, ΔTn, and ΔTa correlated significantly with pathologic

SUBMITTER: Wu Q 

PROVIDER: S-EPMC5620312 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature