Prognostic role of miR-17-92 family in human cancers: evaluation of multiple prognostic outcomes.

ABSTRACT: Recent evidence indicates that miR-17-92 family might be an essential prognostic biomarker for human cancers. However, results are still inconsistent. We therefore performed a meta-analysis to evaluate the predictive role of miR-17-92 family in human cancer prognosis. We searched literatures published before March 31th, 2017 inPubMed, Cochrane and Embase databases. Twenty six studies were included in our analyses. The overall hazard ratios (HRs) showed that high expression level of miR-17-92 family was a predictor of poor overall survival (OS): adjusted HRs = 1.71, 95% confidence intervals (CIs): 1.39-2.11, p < 0.00001, and poor disease-free survival (DFS): adjusted HRs = 2.29, 95% CIs: 1.41-3.72, p = 0.0008. However, no association between miR-17-92 family expression and can

SUBMITTER: Liu F 

PROVIDER: S-EPMC5620325 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature