Retrospective Proteomic Screening of 100 Breast Cancer Tissues.

ABSTRACT: The present investigation has been conducted on one hundred tissue fragments of breast cancer, collected and immediately cryopreserved following the surgical resection. The specimens were selected from patients with invasive ductal carcinoma of the breast, the most frequent and potentially aggressive type of mammary cancer, with the objective to increase the knowledge of breast cancer molecular markers potentially useful for clinical applications. The proteomic screening; by 2D-IPG and mass spectrometry; allowed us to identify two main classes of protein clusters: proteins expressed ubiquitously at high levels in all patients; and proteins expressed sporadically among the same patients. Within the group of ubiquitous proteins, glycolytic enzymes and proteins with anti-apoptotic activity we

SUBMITTER: Pucci-Minafra I 

PROVIDER: S-EPMC5620532 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature