Computed Tomography Measure of Lung at Risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Rationale

The rate of decline of lung function is greater than age-related change in a substantial proportion of patients with chronic obstructive pulmonary disease, even after smoking cessation. Regions of the lung adjacent to emphysematous areas are subject to abnormal stretch during respiration, and this biomechanical stress likely influences emphysema initiation and progression.

Objectives

To assess whether quantifying this penumbra of lung at risk would predict FEV₁ decline.

Methods

We analyzed paired inspiratory-expiratory computed tomography images at baseline of 680 subjects participating in a large multicenter study (COPDGene) over approximately 5 years. By matching inspiratory and expiratory images voxel by voxel using image registration, we calcu

SUBMITTER: Bhatt SP 

PROVIDER: S-EPMC5620667 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature